Feasibility of Sentinel Lymph Node Biopsy in Rectal Cancer

Launched by OXFORD UNIVERSITY HOSPITALS NHS TRUST · May 12, 2015

Keywords

ClinConnect Summary

One issue in managing rectal cancer is identifying which patients will benefit from less radical surgery, which is much safer and better tolerated. However it does not remove lymph nodes where cancer cells may have spread. If lymph nodes containing cancer are left behind, the cancer may recur. So this surgery is only suitable in early rectal cancers not involving lymph nodes. Unfortunately, current investigations do not always accurately identify involved lymph nodes.

Sentinel lymph node biopsy (SLNB) is a technique to surgically remove the first lymph node where cancer cells spread. If th...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • diagnosed with operable rectal cancer
• • case discussed at Oxford Colorectal Cancer multi-disciplinary team (MDT) meeting
• • willing and able to give informed consent
• • willing and able to comply with all trial requirements, in the investigator's opinion
• Exclusion Criteria:
• • females who are pregnant or lactating
• • known intolerance or hypersensitivity to iron, dextran compounds, magnetic tracers or superparamagnetic iron oxide particles (SPIO)
• • cancer involvement of anal sphincter complex
• • adults who are not able to give consent or are deemed vulnerable

Trial Officials