Using Ex-vivo Normothermic Machine Perfusion With the Organox Metra™ Device to Store Human Livers for Transplantation
Launched by UNIVERSITY HEALTH NETWORK, TORONTO · Jun 17, 2015
Trial Information
Current as of May 09, 2025
Unknown status
Keywords
ClinConnect Summary
Liver transplantation is a life-saving procedure but its success has been limited by a shortage of suitable donor organs. Much emphasis is now placed on optimising the condition of those organs that are available, to enable more higher risk organs to be transplanted safely. An effective means of pre-transplant viability assessment would not only allow greater use of higher risk donors but also minimise the risk of primary non-function by identifying and excluding non-viable organs before subjecting a patient to the risk of surgery. Organ storage under normothermic perfusion conditions enabl...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Adult patients (18 years or more)
- • Active on the waiting list for liver transplantation
- • Able to give informed consent
- Exclusion Criteria:
- • Age less than 18 years
- • Acute/fulminant liver failure
- • Transplantation of more than one organ (e.g. liver and kidney)
- • Refusal of informed consent
- • Unable to give informed consent
- • Re-transplantation Diagnosis of Hepatopulmonary Syndrome
About University Health Network, Toronto
University Health Network (UHN), based in Toronto, is a leading academic health sciences center dedicated to advancing patient care through innovative research and education. As a prominent sponsor of clinical trials, UHN integrates cutting-edge scientific discoveries with clinical practice, facilitating the development of new therapies and treatment modalities. With a commitment to improving health outcomes, UHN collaborates with a diverse network of researchers, healthcare professionals, and industry partners, fostering an environment that prioritizes patient safety and ethical standards in clinical research. Through its extensive resources and expertise, UHN plays a pivotal role in transforming healthcare and enhancing the quality of life for patients both locally and globally.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Toronto, Ontario, Canada
Patients applied
Trial Officials
David R Grant, MD
Principal Investigator
University Health Network, Toronto
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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