Rifaximin Use in Severe Alcoholic Hepatitis

Launched by SAINT VINCENT'S HOSPITAL, KOREA · Jun 25, 2015

Keywords

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Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Heavy alcohol drinking within 3 months (Over 40 g/day)
• • Maddrey's discriminant function ≥ 32
• • AST/ALT ration ≥ 2
• • Bilirubin level ≥ 5mg/dL
• • Any one of the following additional criteria : hepatic encephalopathy, enlarged, tender liver, or peripheral leucocytosis
• • Age : 19-75
• • Jaundice within 3 months
• Exclusion Criteria:
• • Other causes of chronic liver disease (HBV, HCV, or autoimmune hepatitis)
• • Antibiotics or probiotics use within 8 weeks
• • Drug induced hepatotoxicity
• • Acute viral hepatitis (HAV or HEV)
• • Hepatic abscess or cholagitis
• • Hepatocellular carcinoma of modified UICC stage II, III or IV
• • Malignant tumor other than HCC
• • Pregnancy
• • Severe chronic extrahepatic disease
• • Type I hepatorenal syndrome
• • Hepatic encephalopathy grade II or IV
• • Severe infection