Gradual Egg-tolerance Induction in Hen's Egg Allergic Children

Launched by DOMINQUE BULLENS · Jun 29, 2015

Keywords

ClinConnect Summary

1. The investigators here want to test the hypothesis that a total period of 18 months of gradual open introduction of a certain egg product with regard to full egg tolerance induction is not inferior when compared to a total period of 30 months gradual open introduction of a certain egg product (see steps for the specific egg products) after tolerance to baked egg has been obtained.
2. The investigators also want to define step-specific 'tolerance-failures' and study the relevance of specific IgE to specific egg components to predict failures at each step.

Step 1: open baked egg test pass...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Children (1-18y) had or have a clinical diagnosis of IgE mediated hen's egg allergy based on positive history as well as skin prick testing and/or specific IgE detection by CAPtest in an allergy clinic
• • 2. Children are at least 12 months old before introduction of heated egg is considered
• • 3. Children did not suffer from a moderate-to-severe anaphylaxis due to egg-ingestion at presentation
• • 4. Children have specific IgE levels to Gal d 1 below 1.2 kU/mL or passed cake provocation test -
• Exclusion Criteria:
• • 1. Children had a moderate-to severe anaphylaxis due to egg ingestion
• • 2. Children are younger than 12 months old at the moment of passing heated egg open provocation test
• • 3. Parents are not able or not willing to test a certain step in the tolerance induction at home -