Comparison of Ticagrelor vs. Prasugrel on Inflammation, Arterial Stiffness, Endothelial Function, and Circulating Endothelial Progenitor Cells in Diabetic Patients With Non-ST Elevation Acute Coronary Syndrome (NSTE-ACS) Requiring Coronary Stenting

Launched by KOREA UNIVERSITY ANAM HOSPITAL · Jun 30, 2015

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Eligibility criteria

• Inclusion Criteria:
• • 1. Provision of informed consent prior to any study specific procedures
• • 2. Newly diagnosed type 2 diabetic patients or type 2 diabetic patients on hypoglycemic agents between the age of 30 to 70
• • 3. Non-ST elevation Acute coronary syndrome with successful coronary stent implantation (with TIMI flow grade 3 after the procedure)
• Exclusion Criteria:
• • 1. Hypersensitivity to ticagrelor, prasugrel or any of the excipients
• • 2. No prior use of either ticagrelor or prasugrel within a month prior to randomization.
• • 3. History of intracranial bleeding at any time
• • 4. Active pathologic bleeding
• • 5. Hemoglobin A1c \>9%
• • 6. Type 1 diabetes
• • 7. Decreased serum platelet level (\< 100,000/uL)
• • 8. Need for chronic oral anticoagulant therapy or chronic low-molecular-weight heparin
• • 9. Gastrointestinal bleed within the past 6 months, or major surgery within 30 days
• • 10. Renal failure requiring dialysis or anticipated need for dialysis during the course of the study
• • 11. Any condition which in the opinion of the investigator would make it unsafe or unsuitable for the patient to participate in this study
• • 12. Involvement in the planning and/or conduct of the study
• • 13. Left ventricular ejection fraction \< 40%
• • 14. Hepatic dysfunction (aspartate aminotransferase or alanine aminotransferase \> twice the upper limit)
• • 15. Gastrointestinal disorder such as Crohn's disease
• • 16. Alcohol abuse
• • 17. Steroid or hormone replacement therapy
• • 18. Serum creatinine \> 2.0 mg/dL.
• • 19. Prior history of CVA or stroke
• • 20. Body weight \< 60 kg
• • 21. Life expectancy less than a year
• • 22. Known pregnancy, breast-feeding, or intend to become pregnant during the study period