Comparison of Two Rescue Therapies for Helicobacter Pylori Infection

Launched by KAOHSIUNG VETERANS GENERAL HOSPITAL. · Sep 9, 2015

Keywords

ClinConnect Summary

The H pylori-infected adult patients with failure of standard triple therapy and H pylori-infected adult patients with failure of non-bismuth quadruple therapy are randomly assigned to either EALT (esomeprazole 40 mg b.d., amoxicillin 500 mg q.d.s., levofloxacin 500 mg o.d., and tetracycline 500 mg q.d.s.) therapy or EAL (esomeprazole 40 mg b.d., amoxicillin 500 mg q.d.s., and levofloxacin 500 mg o.d.) for 10 days. Repeated endoscopy with rapid urease test, histological examination and culture or urea breath tests is performed at six weeks after the end of anti-H pylori therapy.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • positive results of both rapid urease test and histology,
• • a positive result of urea breath test,
• • or a positive result of culture.
• Exclusion Criteria:
• • ingestion of antibiotics, bismuth, or proton pump inhibitor（PPI）within the prior 4 weeks,
• • patients with allergic history to the medications used,
• • patients with previous gastric surgery,
• • the coexistence of serious concomitant illness (for example, decompensated liver cirrhosis, uremia),
• • pregnant women