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Search / Trial NCT02565407

Robot-aided Proprioceptive Rehabilitation Training

Launched by UNIVERSITY OF MINNESOTA · Sep 30, 2015

Trial Information

Current as of May 14, 2025

Completed

Keywords

ClinConnect Summary

This protocol seeks to improve proprioceptive-motor function. Proprioception refers to the perception of limb position or motion and the orientation of one's body in space. Numerous medical conditions with motor symptoms are also associated with proprioceptive loss, such as osteoarthritis, Parkinson's disease, peripheral sensory neuropathy, stroke, and developmental coordination disorder.

However, therapies to improve proprioceptive function in these populations are either non-existent or very limited in scope although it is established that proprioceptive impairments severely degrade moto...

Gender

ALL

Eligibility criteria

  • For all participants (both healthy and patient populations)
  • Inclusion Criteria:
  • 1. wrist passive range of motion (ROM) more than 22.5° in flexion/extension
  • 2. sense the vibro-tactile cues on either forearms in order to effectively receive the movement-related feedback
  • 3. resist minimal resistance in gravity-eliminated position (score at least 2+/5 with the physical examination of manual muscle testing (Hislop, Avers, \& Brown, 2013)) ) in all wrist movement directions.
  • Exclusion Criteria:
  • 1. Regular intake of benzodiazepines.
  • 2. Cognitive impairment: score ≥ 23 on Mini-mental state examination (Folstein, Robins \& Helzer, 1983)
  • 3. Depressive symptoms: score ≤ 19 on Beck depression inventory (Beck, Steer, \& Carbin,1988).
  • Inclusion Criteria for Stroke Subjects
  • 1. at least 3 months after stroke
  • 2. whose age are between 30 to 75 years old.
  • Exclusion Criteria for Subjects undergoing the TMS procedure (Rossi, Hallett, Rossini, \& Pascual-Leone, 2009)
  • Has implanted metal in the body.
  • Diagnosed with multiple sclerosis, major psychiatric conditions, epilepsy, history of seizures in the past 2 years, sleep deprivation, pregnancy, uncontrolled migraine, major traumatic head injury, severe heart disease, increased intracranial pressure, high consumption of alcohol, any conditions that predispose one to seizures
  • Is currently taking any pro-epileptic medication (e.g. epileptogenic drugs such as tricyclic antidepressants)
  • When no electromyography response can be elicited within the range of the TMS stimulator
  • Pregnant at the time of data collection .

About University Of Minnesota

The University of Minnesota is a leading academic institution renowned for its commitment to advancing healthcare through innovative research and clinical trials. With a focus on interdisciplinary collaboration, the university leverages its extensive resources and expertise to conduct cutting-edge studies aimed at improving patient outcomes and addressing critical health challenges. Its robust clinical trial program emphasizes ethical standards, patient safety, and scientific rigor, contributing to the development of novel therapies and interventions that enhance medical practice and public health.

Locations

Minneapolis, Minnesota, United States

Patients applied

0 patients applied

Trial Officials

Juergen Konczak, Ph.D

Principal Investigator

University of Minnesota

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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