Preoperative BNP as Biomarker of Postoperative Cardiovascular Complications

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DE NICE · Oct 6, 2015

Keywords

ClinConnect Summary

The morbidity and mortality of non-cardiac major surgery is mainly due to cardiovascular complications. BNP is a hormone for predicting preoperatively the occurrence of these complications. Widely used in cardiac surgery, it is not routinely used in non-cardiac major surgery. His interest in this type of surgery has yet been proven by numerous studies.

In practice, the problem with this biomarker is the pratitioner do not know the most opportune moment for the preoperative dose or what threshold used to classify our patient patients at risk of cardiovascular complication or not at risk.

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Eligibility criteria

• Inclusion Criteria:
• • Major patients who was not opposed to one additional sample
• • Who have to undergoing moderate or high cardiovascular risk non-ambulatory scheduled surgery with the exception of cardiac surgery
• • With predictable delay between the preoperative evaluation and the surgery \> 15 days
• Exclusion Criteria:
• * Moderate cardiovascular risk surgeries (1-5%):
• • Carotid Endarterectomy
• • Surgery of the Head and Neck
• • Thoracic surgery and intraperitoneal (thromboembolism)
• • Orthopaedic surgery (thromboembolism)
• • Prostate Surgery (thromboembolism)
• High cardiovascular risk surgeries (\> 5%):
• • Aortic surgery with risk of sudden changes in blood pressure during clamping (acute pulmonary edema, ischemia)
• • declamping (coronary perfusion)
• • other major vascular surgery - peripheral vascular surgery - long surgery with significant blood loss or fluid and electrolyte