Tranexamic Acid and Ethamsylate For Preventing PPH in Patient Undergoing LSCS at High Risk For PPH

Launched by AHMED ALANWAR · Nov 12, 2015

Keywords

ClinConnect Summary

Research Question:

Is the combination of Tranexamic acid and Ethamsylate is more effective than oxytocin alone for preventing postpartum hemorrhage if they are given after delivery of the fetus ?

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Women undergoing elective caesarean section
• • 2. Patient having one or more risk factor for PPH
• • Multiple pregnancy
• • Polyhydramnios (AFI \>25cm)
• • Macrocosmic baby (\>4.5 Kg)
• • Prolonged , augmented and obstructed labour
• • Obese patients(BMI \>30)
• • Premature rapture of membranes
• • Previous history of PPH
• • 3. Age ≥18 years
• • 4. Gestational Age ≥ 35 Weeks
• • 5. Informed Oral Consent From The Patient
• Exclusion Criteria:
• • 1. History of venous thrombosis (DVT and/or Pulmonary embolism) OR arterial thrombosis (angina pectoris , myocardial infarction, stroke)
• • 2. History of epilepsy or seizure
• • 3. Any Known Cardiovascular , renal or liver Disease
• • 4. Autoimmune Diseases
• • 5. Sickle Cell Disease
• • 6. Severe hemorrhagic Disease
• • 7. Placenta Previa.
• • 8. Morbidly adherent Placenta
• • 9. Abruptio placenta
• • 10. Eclampsia, hemolysis, elevated liver enzymes, and low platelet count syndrome
• • 11. Administration Of low molecular weight heparin or Anti platelets the week before delivery .