Learning and Relapse Risk in Alcohol Dependence (FP2)

Launched by TECHNISCHE UNIVERSITÄT DRESDEN · Nov 25, 2015

Keywords

ClinConnect Summary

This Project will examine 130 detoxified alcohol-dependent patients and 40 age- and gender matched controls. All subjects will be treated with Zooming Joystick Task (ZJT) training to alter a habitual alcohol cue approach bias. The primary aim of this project is to assess

1. which behavioural and neuroimaging alterations (fMRI) associated with reward-based learning are altered by ZJT treatment and which alterations predict treatment outcome (primary outcome: relapse, secondary outcome: amount of alcohol intake) within the follow-up period of 6 months,
2. how these alterations interact with ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Men and women aged 18-65 years
• • alcohol dependence/alcohol use disorder according to ICD-10 and alcohol-use disorder according to DSM-5
• • Minimum of 72 hours of abstinence, maximum of 21 days of abstinence
• • Minimum of three years with alcohol dependence/alcohol use disorder
• • Low severity of withdrawal symptoms
• • Ability to provide fully informed consent and to use self-rating scales
• • Sufficient understanding of the German language
• Exclusion Criteria:
• • Lifetime history of DSM-IV bipolar, psychotic disorder, or substance dependence other than nicotine dependence. Patients may have had lifetime alcohol dependence/alcohol use disorder diagnoses.
• • Current threshold DSM-IV diagnosis of any of the following disorders: current (hypo)manic episode, major depressive disorder, generalized anxiety disorder, PTSD, borderline personality disorder, or obsessive compulsive disorder
• • History of substance dependence other than alcohol or nicotine dependence
• • Current substance use other than nicotine and alcohol as evinced by positive urine test
• • History of severe head trauma or other severe central neurological disorder (dementia, Parkinson's disease, multiple sclerosis)
• • Pregnancy or nursing infants
• • Any alcohol intake within the last 24 hours
• • Use of medications or drugs known to interact with the central nervous system within the last 10 days, except detoxification treatment with benzodiazepines or clomethiazole, with testing at least four half-lives post last intake