Pulmonary Vein Reconnection Following Ablation Index-guided Ablation: a Success Evaluation

Launched by LIVERPOOL HEART AND CHEST HOSPITAL NHS FOUNDATION TRUST · Dec 9, 2015

Keywords

ClinConnect Summary

The study is a prospective cohort study in 40 patients with Persistent AF. It will comprise two groups:

1. Active Group (AI guided ablation): An initial pulmonary vein isolation (PVI) procedure will be performed guided by AI targets. All patients (regardless of AF recurrence) will undergo a repeat EP study at 8-10 weeks to identify and re-ablate site(s) of PV reconnection
2. Historical control group (Contact Force Guided Ablation): will be formed by the 40 patients enrolled to the repeat study arm of the PRESSURE study (ClinicalTrials.gov Identifier: NCT01942408). All 40 patients underwent...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged over 18 years
• • Persistent AF (defined, according to the ESC/EHRA Guidelines for the Management of Atrial Fibrillation 2010, as AF episode that either lasts longer than 7 days or requires termination by cardioversion, either with drugs or by direct current cardioversion (DCC) ).
• • Symptomatic in spite of drug treatment
• • Due to undergo pulmonary vein isolation by RF ablation
• Exclusion Criteria:
• • Inability or unwillingness to receive oral anticoagulation with a Vitamin K antagonist (VKA) or non-VKA (NOAC) agent
• • Previous catheter or surgical ablation procedure for AF
• • Unwillingness or inability to complete the required follow-up arrangements
• • Current pattern of paroxysmal AF
• • Long standing persistent AF (continuous AF longer than 12 months before ablation)
• • Prior prosthetic mitral valve replacement or severe structural cardiac abnormality
• • Known infiltrative cardiomyopathy
• • Known severe left ventricular systolic function (ejection fraction \<35%)
• • Pregnancy