High Fluence Light Emitting Diode-Red Light (LED-RL) in Human Skin

Launched by JARED JAGDEO, MD, MS · Dec 10, 2015

Keywords

ClinConnect Summary

Skin fibrosis is involved in a variety of pathologic processes ranging from exuberant scar formation secondary to surgery or trauma, as in hypertrophic and keloid scars, to immune-mediated processes such as scleroderma and chronic graft-versus-host disease. As highlighted by quality-of-life studies, skin fibrosis imparts a significant socioeconomic burden due to the functional, aesthetic, and psychosocial impact it has on a patient's life. The effects of visible light, while common in the environment (visible spectrum accounts for 44% of total solar energy), remain undefined. An important s...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy subjects of any sex, ethnicity and age
• • Nondominant proximal anterior forearm is wide enough to ensure reproducible placement of LED-RL phototherapy or mock therapy hand-held unit
• • Available and willing to attend all clinic visits
• • Able and willing to give informed consent
• Exclusion Criteria:
• • Subjects using any photosensitizers (i.e. lithium, melatonin, phenothiazine antipsychotics, antibiotics)
• • Subjects with diabetes mellitus (DM)
• • Subjects with a history of skin cancer; basal cell carcinoma (BCC) or squamous cell carcinoma (SCC).
• • Subjects with systemic lupus erythematous (SLE)
• • Subjects with any other medical condition that could be compromised by exposure to the proposed treatment
• • Subjects with light-sensitive conditions or on photosensitizing medications (All subjects will be tested for photosensitivity per manufacturer user guide instructions)
• • Subjects with open wounds on the nondominant proximal anterior forearm
• • Subjects with fibrotic skin disease or other skin conditions on the nondominant proximal anterior forearm
• • Subjects with tattoos that cover the procedure site on the nondominant proximal anterior forearm