Mechanical Insufflator-exsufflator to Control Mucus Hypersecretion in Patients in Palliative Care - A Feasibility Study

Launched by UNIVERSIDADE FEDERAL DE SAO CARLOS · Jan 7, 2016

Keywords

ClinConnect Summary

Investigators will conduct a feasibility study for a future fast track randomized trial, which will be carried out in the Américo Brasiliense State Hospital and conducted by the Spirometry and Respiratory Physiotherapy Laboratory from the Federal University of São Carlos, Brazil.

The concept of feasibility is defined as "capable of being done or carried out" and studies which aim is to verify the feasibility intends to verify if a larger clinical trial would have a acceptable probability of success in proving the efficacy of an intervention 24. The importance of feasibility studies has bee...

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ALL

Eligibility criteria

• Inclusion Criteria:
• * Prognosis:
• • Less than one year assessed by the responsible physician, with a negative answer of the to the "surprise question" - Would you be surprised if this patient died in the following year?
• • Higher than 3 months, assessed by the same physician
• * Patients with problems to deal with secretions, which could be one or both of the following problems:
• • Hypersecretion
• • Cough inefficiency (peak cough flow \<250L/min)
• • Karnofsky Performance Status Scale higher or equal to 30%;
• • Ability to give written informed consent or presence of a person who is responsable for the patient
• Exclusion Criteria:
• * Patients with conditions considered as contra-indication for the use of Mechanical Insufflator-Exsufflator:
• • Bullous emphysema history
• • Known susceptibility for pneumothorax or pneumo-mediastinum
• • Known to have had any recent barotrauma.