Time-Lapse Incubation for Embryo Culture - Morphokinetics and Environmental Stability

Launched by SHAARE ZEDEK MEDICAL CENTER · Jan 13, 2016

Keywords

ClinConnect Summary

Research Objectives:

We are now reaching a new age with an opportunity to advance to theoretically better culture environments and improvements on measures of embryo assessment.

The objectives of this research study will be to evaluate and compare the reproductive outcomes in isolating one of two new interventions introduced by the Time-Lapse Incubator (TLI) system. The first will be an assessment of the TLI environment compared to the standard Bench Incubator (BI) environment. The second will be an assessment of the added morphokinetic grading of embryos compared to the traditional morph...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• * Patients requiring assisted reproductive technologies for one or more of the following reasons:
• • Male factor infertility
• • Unexplained infertility
• • Mechanical factor infertility
• • Ovulatory infertility
• • Patients undergoing fertility treatment at Shaare Zedek Medical Centre alone.
• • Patients attempting pregnancy with autologous gametes.
• • Patients receiving embryo transfers according to the Israel Society of Obstetrics and Gynecology guideline on number of embryos for transfer during in vitro fertilization.
• • Patients undergoing their first or second ICSI cycle (cumulative to all other institutions involved in prior treatment) since their previous pregnancy.
• • BMI criteria: \>18 and \<30 kg/m2
• Exclusion Criteria:
• * An infertility diagnosis that includes the following:
• • Severe male factor infertility requiring testicular aspiration, testicular biopsy for sperm retrieval, or less than 1000 sperm per ejaculate.
• • Untreated hydrosalpinx
• • Persistently thin endometrial lining or endometrial factor
• • Severe Endometriosis
• • Low ovarian reserve (≤8 antral follicle count (AFC) follicles measuring 2 to 10 mm in diameter on day 2-4 of menstrual cycle, or day 3 follicle stimulating hormone (FSH) ≥10 milli-International unit (mIU) /mL)
• • High risk for Ovarian Hyperstimulation Syndrome (Estradiol level \>13 000 pmol/L or \>20 follicles ≥16 mm diameter during controlled ovarian hyper stimulation, ≥20 oocytes collected).
• • Patients obtaining GnRH agonist for final follicular maturation
• • Patients requiring preimplantation genetic diagnosis (PGD)
• • Patients who require freezing of all oocytes or embryos
• • More than 2 previous cycles of IVF since previous pregnancy
• • Current smokers