Pain In Neuropathy Study

Launched by KING'S COLLEGE LONDON · Jan 29, 2016

Keywords

ClinConnect Summary

Very little is currently known about why some patients with peripheral neuropathy develop neuropathic pain, whilst others do not. It is anticipated that this study will begin to identify features of the peripheral neuropathy, which are and are not, associated with the development and intensity of neuropathic pain and therefore begin to elucidate factors, which underlie pain. We will also compare findings in neuropathies resulting from diverse aetiologies including diabetes, HIV and idiopathic axonal neuropathies in order to investigate, whether there are differences in pain symptomatology, ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients who are ≥18 years of age who have a diagnosis of peripheral neuropathy based on a prior clinical assessment combined with supportive clinical investigations such as abnormal nerve conduction studies, reduced intraepidermal nerve or abnormal findings on quantitative sensory testing.
• • If supportive clinical investigations (as described above) are not available at entry into the study a neuropathy disability scale ≥3 (Pham et al., 2000).
• • And patients with symptoms highly suggestive of neuropathy that in the judgement of the clinical researcher are suitable for the study even if they do not fulfill other inclusion criteria.
• • Patients who do not fulfill any of the exclusion criteria.
• Exclusion Criteria:
• • Subjects who are pregnant.
• • Subjects with insufficient command of English to obtain consent from or to complete the study questionnaires.
• • Subjects with insufficient mental capacity to obtain consent from or complete study questionnaires.
• • Subjects with concurrent severe psychological or psychiatric disorders.
• • Patients with moderate to severe pain form other causes that may confound assessment or reporting of pain (eg. spinal canal stenosis).
• • Patients with central nervous lesions, which may complicate somatosensory testing.
• • Who is in the opinion of the investigator unsuitable for participation in the study.
• • Skin biopsies will not be conducted on patients that are anticoagulated or who have any other contra-indication to skin biopsy (if patients decline a skin biopsy they will NOT be excluded from the study).