Biomarker Analysis of Central Nervous System Tumors

Launched by NATIONAL CANCER INSTITUTE (NCI) · Feb 25, 2016

Keywords

ClinConnect Summary

BACKGROUND

* Central Nervous System (CNS) and brain tumors are a heterogeneous group of neoplasms. They can be broadly categorized to tumors of neuroepithelial tissue, meninges, hematopoietic system, germ cells, and sella.
* The Central Brain Tumor Registry of the United States reports an overall average annual age-adjusted incidence rate for the years 2006-2010 for primary brain and CNS tumors as 21.03 per 100,000. This leads to an estimated mortality of over 13,000 deaths per year. Although this number is small compared to other more common cancers, due to the location of CNS (brain and ...

Gender

ALL

Eligibility criteria

• * ELIGIBILITY CRITERIA:
• • Diagnosis of CNS neoplasm.
• • Eligible cases include those in which primary diagnostic studies are complete, and for which there is excess tissue for analysis in the form of unstained slides or paraffin blocks archived in the NCI CCR Laboratory of Pathology as well as imaging stored in the NIH medical records system. Cases will be drawn from specimens previously submitted to the NCI CCR Laboratory of Pathology in consultation or from surplus materials from existing protocols, upon completion of all superseding diagnostic tests and medical/scientific studies in cases where the patient is deceased or has previously consented to future use of samples on their original protocol consent. Inclusion of additional NIH cases will be limited to those instances in which the current informed consent encompasses the proposed analyses.