Levofloxacin in Bacterial Rhinosinussitis

Launched by DR. REDDY'S LABORATORIES LIMITED · Mar 14, 2016

Keywords

ClinConnect Summary

Inflammatory diseases of paranasal sinuses occupy one of the leading positions in the overall structure of ENT-diseases.

Puncture method has been a conventional approach to the treatment of suppurative maxillary sinusitis in Russia until present. However, this relatively simple and conventional treatment method has a number of disadvantages. Fear of an unpleasant procedure is justified. Generally, single puncture does not ensure healing, and the doctor has to install drainage or of perform repeated manipulations significantly reducing quality of life during the disease period. There is als...

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Signed informed consent form.
• • Males and females aged 18-60 years old
• • Hospitalized subjects with verified diagnosis of moderate/severe acute bacterial rhinosinusitis
• • Readiness to comply with medical recommendations.
• • Assessment of objective and subjective symptoms of the disease \>= 3 points
• Exclusion Criteria:
• • Previous nasal surgery within the last 6 months
• • Participation in other studies
• • Polypous rhinosinusitis
• • Concomitant therapy affecting the study results (psychotropic drugs, alpha-adrenoreceptor antagonists, antihistamine drug, antibiotics, cromones, corticosteroids) within the last month
• • Need in cromones, antihistamine drugs, corticosteroids (moderate and severe allergic rhinitis)
• • Severe somatic diseases in the past medical history: severe endocrine pathologies, severe cardiovascular diseases, renal and/or hepatic failure, oncology
• • Subject's inability to perceive instructions for the study procedure
• • Pregnancy, lactation
• • Signs of a dangerous infectious disease.