Dexmedetomidine vs. Midazolam Sedation for Endobronchial Ultrasound
Launched by POST GRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH, CHANDIGARH · Mar 14, 2016
Trial Information
Current as of May 10, 2025
Completed
Keywords
ClinConnect Summary
Benzodiazepines, opioids, and propofol are currently used alone or in combination for achieving sedation during endobronchial ultrasound and other bronchoscopic procedures. However, all these agents carry a risk of respiratory depression. Dexmedetomidine, a highly selective adrenergic alpha-2 agonist, has sedative and analgesic properties but does not cause respiratory depression. This study aims to compare efficacy and safety of dexmedetomidine as a sedative to midazolam in patients with hilar/mediastinal lymphadenopathy undergoing convex-probe endobronchial ultrasonography on day care bas...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Age 18 years or more
- • American Society of Anesthesiologists physical status I or II
- • Presence of hilar and/or mediastinal lymph nodes on thoracic CT scan
- Exclusion Criteria:
- • Known allergy to dexmedetomidine or midazolam or fentanyl
- • Documented coagulopathy
- • Pregnancy
- • Hemodynamic instability (hypotension, arrhythmia, recent acute coronary event)
- • Neuropsychiatric illness
- • History of previous endobronchial ultrasound procedure
- • Refusal to provide consent
About Post Graduate Institute Of Medical Education And Research, Chandigarh
The Post Graduate Institute of Medical Education and Research (PGIMER) in Chandigarh is a premier institute dedicated to advancing medical education, research, and healthcare delivery in India. Renowned for its commitment to excellence, PGIMER plays a pivotal role in conducting cutting-edge clinical trials that contribute to the development of innovative therapies and improve patient outcomes. With a multidisciplinary approach and a team of highly qualified professionals, PGIMER fosters a collaborative environment for research, aiming to enhance medical knowledge and practice through rigorous scientific inquiry and evidence-based solutions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Chandigarh, , India
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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