Characterization of the Analgesic Effect of CBD in Healthy, Normal Volunteers

Launched by UNIVERSITY OF CALIFORNIA, LOS ANGELES · Apr 21, 2016

Keywords

ClinConnect Summary

This within-subject, double-blind, placebo-controlled study will assess the analgesic and subjective effects of a range of CBD doses (0, 200, 400, or 800 mg, po). Volunteers will participate in 4 outpatient laboratory sessions over the course of 4 weeks during which the analgesic effects of CBD will be assessed using the Cold-Pressor Test (CPT), a laboratory model of pain which has predictive validity for the clinical use of analgesics. The order of CBD dose will be randomized across participants. Secondary measures will include subjective and physiologic effects of CBD.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Able to perform study procedures
• • Women practicing an effective form of birth control
• Exclusion Criteria:
• • Female subjects who are currently pregnant or breastfeeding.
• • Current illicit drug use
• • Presence of significant medical illness
• • History of heart disease
• • Request for drug treatment
• • Current parole or probation
• • Recent history of significant violent behavior
• • Major psychiatric disorder
• • Current use of any prescription or over-the-counter medication
• • Current pain
• • Clinically significant Raynaud's syndrome