Autologous Cell-derived Tissue Engineered Cartilage for Repairing Articular Cartilage Lesions

Launched by CHINESE PLA GENERAL HOSPITAL · May 11, 2016

Keywords

ClinConnect Summary

Injured articular cartilage has limited capacity for self repair. Without timely, early and effective treatment, damage to the articular cartilage progressively worsens, resulting in joint swelling, pain and dysfunction. The patient ultimately develops osteoarthritis and will be required to undergo artificial joint replacement. Clinical therapy for cartilage damage includes microfracture surgery and autologous osteochondral transplantation. However, the microfracture technique is limited to small-scale damage, and autologous osteochondral transplantation is hindered by limited supply. With ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with full-thickness cartilage injury in knee and ankle joints
• • Patients with normal joint movement and stable joint (without injury or less than 1/3 excision of the meniscus; normal cruciate ligament, lateral and medial collateral accessory ligament, or normal Q angle and patellofemoral joint trajectory after transplantation, or corrected to normal by surgery), without valgus or varus deformity
• • Patients 14-50 years of age.
• • Patients with focal cartilage defects diagnosed by arthroscopy, Outerbridge III/IV grade, cartilage defect size 2.5-10 cm2, intact articular surface (lower than grade II injury according to Outerbridge classification), one or two lesions in the same joint.
• • Patients and their families are informed of the treatment and provide signed informed consent.
• Exclusion Criteria:
• • Poor health
• • Blood diseases
• • Topical steroid therapy within three months
• • Bleeding tendency
• • Drug addiction (including narcotic, anesthetic or alcohol addiction)
• • Inflammatory joint disease (specific or non-specific arthritis)
• • Contagious viral infection
• • Metabolic diseases (gout or rheumatism)
• • Body mass index \> 30 kg/m2
• • Pregnant or lactating women, or planning to become pregnant within 1 year after initial registration
• • Psychological mental illness, cannot cope with rehabilitation