Maggot Debridement Therapy Versus Conventional Dressing Therapy to Treat Diabetic Foot Ulcers

Launched by THE FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIVERSITY · Jun 24, 2016

Keywords

ClinConnect Summary

The investigators designed a prospective randomized study to compare the clinical safety and efficacy of maggot debridement therapy (MDT) and conventional dressing therapy (CDT). This study is scheduled from July 2016 to February 2017. Patients, aged from 18-80, who suffered from type 2 diabetic mellitus foot ulcers with Grade 1 or Grade 2 according to the Wagner classification could be the participants of this study. A sample of 138 participants was calculated based on the morbidity of diabetic foot ulcers, accounting for estimated 10% attrition rate. The glycemic control is important for ...

Gender

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Eligibility criteria

• Inclusion Criteria:
• • 1. Participants aged from 18-80 years old.
• • 2. Participants with type 2 diabetes mellitus longer than one year, foot ulcer longer than three weeks and with ischemic symptoms of lower limb.
• • 3. The ulcer erosion depth is not reached and muscle layer.
• • 4. The Wagner classification of ulcers should be Grade 1 or Grade 2.
• • 5. Blood glucose control: Fasting blood glucose ≤ 8mmol / L; Postprandial blood glucose two hours ≤ 11.1 mmol / L.
• • 6. Participants do not receive ulcer wound management in the past three days when recruited.
• • 7. Participants with neuropathy symptoms, such as limb numbness, tingling or pain, especially pain at night.
• Exclusion Criteria:
• • 1. Participants with acute thrombosis that required thrombolysis or thrombectomy.
• • 2. Participants with severe systemic infection.
• • 3. Participants who are sensitive to pain.
• • 4. Participants with bone/joint deformities of foot (eagle claw toes, hammer toes)