Frequency Of MCP-1 And CCR2 Gene Polymorphisms And Its Effect On Gene Expression In Patients With AgP

Launched by ABANT IZZET BAYSAL UNIVERSITY · Jun 28, 2016

Keywords

ClinConnect Summary

Differences in structure of gene or non genetic factors such as nutrition/environmental factors may alter functional gene product: mRNA/protein which play crucial roles in immune system. This can lead developing defective immune responses, exacerbation of current inflammation and increased host susceptibility to inflammatory diseases. Monocyte functions can be critical with regard to getting individuals susceptible to periodontitis. Similarly Garrison and Nichols (1989) reported that hyper-inflammatory monocyte phenotype can be deterministic in periodontal destruction. For this reason, regu...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Periodontally H control group had \< 3mm PD, \< 2 GI and no signs of interproximal attachment loss and a history of periodontal disease.
• • The AgP group included individuals diagnosed with localized AgP (LAgP) or generalized AgP (GAgP) who were otherwise healthy. Periodontal attachment loss ≥4 mm not involving more than two permanent teeth, other than the first molars and incisors were diagnosed with LAgP (n: 43); patients with involvement of at least three teeth, other than the first molars and incisors with an attachment loss ≥4 mm were diagnosed with GAgP
• Exclusion Criteria:
• • Patients who have any systemic diseases or conditions that could effect the periodontium
• • hepatitis and/or immunodeficiency virus infection
• • a history of periodontal treatment and antibiotic therapy within the 6 months
• • \< 16 teeth in their mouth
• • Subjects who had smoked and were ongoing orthodontic treatment were excluded.