β-alanine Supplementation on Knee Extensor Contractile and Force Properties

Launched by NOTTINGHAM TRENT UNIVERSITY · Jun 27, 2016

Keywords

ClinConnect Summary

Carnosine (β-alanyl-L-histidine) is a naturally occurring dipeptide formed by bonding histidine and β-alanine in a reaction catalysed by carnosine synthase. One role of carnosine within the human system, is as an intracellular pH buffer due to its pKa of 6.83. Carnosine is suitable over the whole exercise induced intramuscular pH transit-range. Carnosine in untrained populations can neutralise 2.4 to 10.1mmol H+.kg-1 of dry mass muscle as intramuscular pH declines, adding at least 7% to 10% to total intramuscular buffering capacity. It has also been argued that carnosine in combination with...

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • physically active
• • male
• Exclusion Criteria:
• • vegetarian/vegan
• • have been using β-alanine or carnosine supplements within the past 6 months
• • Bone disorders in the assessed lower limb, sustained within the previous 2 years, including osteoarthritis, osteoporosis, bone cyst and osteopenia.
• • Non-arthroscopic joint surgery, or joint replacement, ever, in the assessed limb (knee, hip and ankle).
• • Lower limb leg injuries including sprains and strains, joint dislocations and fractures.
• • Regular knee pain in the assessed limb when performing daily movement tasks.
• • Participation within a resistance training programme in the last 6 months