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Search / Trial NCT02830399

Clinical Trial on Efficacy of rTMS to Improve ECT in Treatment-Resistant Depression

Launched by CENTRE HOSPITALIER DU ROUVRAY · Jul 8, 2016

Trial Information

Current as of May 01, 2025

Completed

Keywords

Treatment Resistant Depression R Tms Ect Augmentation Strategy

ClinConnect Summary

Included patients are adults, aged between 18 and 70 years, with major depression (Hamilton Rating scale for Depression, HAMD ≥ 15). Patients don't have any experience concerning repeated Transcranial Magnetic Stimulation (rTMS).

Patients with treatment-resistant depression (TRD) were assigned to two treatment groups in addition to their current pharmacotherapy regimen : one group received 5 active-rTMS before Electroconvulsive therapy (ECT) and the other one received sham-rTMS before ECT. The depressive symptoms and the cognitive functions are evaluated before rTMS, after 5 rTMS and after...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Patients with Major Depressive Disorder (HAMD≥15)
  • Level of resistance ≥ 3 (Thase and Rush)
  • Participants who gave their informed, written consent
  • Exclusion Criteria:
  • Contraindication of Electroconvulsive therapy (ECT), repeated Transcranial Magnetic Stimulation (rTMS), Magnetic Resonance Imaging (MRI), anesthesia
  • History of epilepsy; severe neurological or systemic disorder that could significantly affect cognition
  • Pregnancy

About Centre Hospitalier Du Rouvray

The Centre Hospitalier du Rouvray is a leading psychiatric hospital located in France, dedicated to advancing mental health care through innovative research and clinical trials. With a commitment to enhancing patient outcomes, the institution focuses on a multidisciplinary approach, integrating clinical expertise with cutting-edge methodologies. The Centre Hospitalier du Rouvray collaborates with various stakeholders, including academic institutions and healthcare organizations, to develop and evaluate novel treatment interventions and therapeutic strategies. Its research initiatives aim to address critical challenges in mental health, contributing to the global body of knowledge and fostering improvements in psychiatric care.

Locations

Caen, , France

Poitiers, , France

Sotteville Lès Rouen, , France

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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