Metabolic Consequences of Gastrointestinal Surgery
Launched by CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST · Jul 14, 2016
Trial Information
Current as of April 30, 2025
Terminated
Keywords
ClinConnect Summary
The role of the gut hormone axis in glucose control is of significant interest due to its proven translational impact in diabetes management. It is also significantly altered by gastric surgery, a procedure that can lead to deleterious symptoms (dumping syndrome) in lean, non-diabetic patients. The investigators will study a unique cohort of young, lean patients undergoing surgery for the prevention of gastric cancer, as well as patients undergoing surgery for gastric and oesophageal cancer, to further understand the regulation and pathophysiological role of the gut hormone axis. The prophy...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Have undergone previous oesophageal or gastric resection
- Exclusion Criteria:
- • Age \<18
- • Recent history of untreated anaemia
- • Donated blood in preceding 16 weeks
- • Lack capacity to read and retain information about study
- • Have a known allergy to interventional agent
- • Have received a course of antibiotics in preceding two months
- • Be on medication that interacts with intervention
- • Have a history of C. difficile colitis
About Cambridge University Hospitals Nhs Foundation Trust
Cambridge University Hospitals NHS Foundation Trust is a leading healthcare organization in the UK, dedicated to advancing medical research and improving patient care through innovative clinical trials. As a prominent academic health science center, it integrates cutting-edge research with clinical practice, fostering collaboration between healthcare professionals, researchers, and patients. The Trust is committed to delivering high-quality, evidence-based healthcare while actively participating in the development of new therapies and interventions aimed at enhancing health outcomes. With a focus on excellence in clinical research, Cambridge University Hospitals aims to translate scientific discoveries into effective treatments, ultimately benefiting the wider community.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Cambridge, Cambridgeshire, United Kingdom
Cambridge, , United Kingdom
Patients applied
Trial Officials
Geoffrey P Roberts, MA BM BCh
Principal Investigator
University of Cambridge
Fiona M Gribble, PhD
Principal Investigator
University of Cambridge
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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