Synovitis and Therapy Response in Inflammatory Arthritis With Contrast Enhanced Ultrasound
Launched by UNIVERSITY OF SOUTHERN CALIFORNIA · Sep 9, 2016
Trial Information
Current as of May 22, 2025
Completed
Keywords
ClinConnect Summary
Inflammatory arthritis affects approximately 1% of the world population and can lead to significant pain and disability. Although radiographs can identify characteristic patterns of joint space narrowing and erosive changes, these findings are typically late findings and represent irreversible damage. With the development of disease modifying anti-rheumatic drugs (DMARDs), the goal is now to identify the pre-erosive inflammatory features and identify the patients that progress further into severe functional debility if not treated immediately.
MRI with gadolinium enhancement is proven to b...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Patients (≥ 18 years of age) that meet diagnostic criteria for an inflammatory arthritis.
- • Clinical suspicion of active synovitis involving at least one target joint.
- • Patients competent to sign study specific Informed Consent.
- • Patients willing to comply with protocol requirements.
- • Intent to treat with disease-modifying anti-rheumatic drugs (DMARDs).
- Exclusion Criteria:
- • Patients who are pregnant or less than 18 years of age.
- • Patients who have a known cardiac shunt or pulmonary hypertension.
- • Patients with any known hypersensitivity to perflutren or gadolinium contrast agents or renal insufficiency (GFR \< 30 mL/min).
- • Patients who cannot consent for themselves.
About University Of Southern California
The University of Southern California (USC) is a prestigious research institution located in Los Angeles, California, known for its commitment to advancing knowledge and innovation in various fields, including medicine and health sciences. As a clinical trial sponsor, USC leverages its extensive resources, interdisciplinary expertise, and state-of-the-art facilities to conduct cutting-edge research aimed at improving patient outcomes and public health. The university fosters collaboration among its diverse faculty and students, ensuring a dynamic environment for the development and implementation of clinical studies that adhere to the highest ethical and scientific standards. Through its clinical trials, USC aims to contribute to the advancement of medical science and the translation of research findings into practical applications that benefit communities locally and globally.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Los Angeles, California, United States
Patients applied
Trial Officials
George R Matcuk, MD
Principal Investigator
University of Southern California
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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