Acute Unilateral Vestibulopathy and Corticosteroid Treatment

Launched by LUND UNIVERSITY · Sep 20, 2016

Keywords

ClinConnect Summary

Randomized controlled trial in 3 arms to see if a short or a even shorter period of steroid treatment on patients diagnosed with vestibular neuritis can be as effective as the only comparable study thus far (Strupp et al, NEJM 22, 351(4) 354-61). If a shorter treatment with a lower dose has the same outcome, then more patients might be eligible for the treatment as many are excluded due to risk for adverse effects.

Corticosteroid treatment in acute unilateral vestibulopathy has recently been the subject for a Cochrane review with the conclusion of insufficient evidence for treatment effect...

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Eligibility criteria

• Inclusion Criteria:
• • definite unilateral vestibulopathy
• • no pathological HINTS (examination criteria in acute vestibular syndrome)
• • capable of making their own decisions
• Exclusion Criteria:
• • tinnitus or hearing loss with same debut as vertigo
• • history of bleeding peptic ulcer
• • glaucoma
• • pregnancy or non-acceptance to use anticonception measures during 13 days after debut
• • high blood pressure \>180 systolic, 105, diastolic
• • ketoacidosis with a Base Excess \>=2
• • psychic disorder (not including mild depression)
• • serious infection (neutropenia, tuberculosis)
• • chronic otitis
• • history of vertiginous disease; Ménière, Vertiginous migraine, atypical BPPV