Levetiracetam Versus Sodium Valproate in Children With Refractory Generalized Convulsive Status Epilepticus

Launched by BANARAS HINDU UNIVERSITY · Sep 28, 2016

Keywords

ClinConnect Summary

In our study patients were considered to have RSE if children were still having active convulsions despite receiving injection lorazepam intravenously at a dose of 0.1 mg/kg (max 4 mg) at a rate maximum upto 2 mg/min or intravenous diazepam at a dose of 0.2 - 0.3 mg/Kg (maximum 10 mg) slowly or intravenous midazolam at a dose of 0.15 - 0.2 mg/kg(max 5 mg). In case of children with difficult intravenous access buccal/nasal midazolam 0.2 - 0.3 mg/kg (maximum 5 mg) per rectal diazepam 0.5 mg/kg (maximum 10 mg) or intramuscular midazolam 0.2 mg/kg (maximum 5 mg). If seizure continued at 5 minut...

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Eligibility criteria

• Inclusion Criteria:
• • 1. Age - 1 year to 16 years
• • 2. Gender - male and female both
• • 3. Refractory generalized convulsive status epilepticus i.e. not responding to any two of the first line drugs
• Exclusion Criteria:
• • 1. Patients with epilepsia partialis continua.
• • 2. Patients with definite history of any allergic reaction to intravenous levetiracetam or intravenous valproate, or any contraindications in giving these drugs.