Redox Status and Immune Function
Launched by NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS · Oct 7, 2016
Trial Information
Current as of June 18, 2025
Completed
Keywords
ClinConnect Summary
The major thiol-disulfide couple of GSH and oxidized glutathione (GSSG) is a crucial regulator of the main transcriptional pathways regulating aseptic inflammation and recovery of skeletal muscle following aseptic injury. Antioxidant supplementation may hamper exercise-induced inflammatory responses.
The objective was to examine how thiol-based antioxidant supplementation affects immune mobilization following exercise-induced skeletal muscle microtrauma. In a two-trial, double-blind, crossover, repeated measures design, 10 young men received either placebo or NAC (20 mg/kg/day) immediately...
Gender
MALE
Eligibility criteria
- Inclusion Criteria:
- • Recreationally trained (VO2max \> 45 ml/kg/min)
- • Engaged in regular exercise for ≥3 times/week for \> 12 months
- • non-smokers
- • Abstain from exercise during the course of the two trials
- • No consumption of performance-enhancing substances, antioxidants, caffeine, alcohol and/or medications during the study.
- Exclusion Criteria:
- • NAC intolerance
- • Recent musculoskeletal injuries of the lower limbs
- • Febrile illness
- • History of muscle lesion.
About National And Kapodistrian University Of Athens
The National and Kapodistrian University of Athens is a prestigious academic institution in Greece, renowned for its commitment to advancing medical research and education. With a strong emphasis on interdisciplinary collaboration, the university fosters innovative clinical trials aimed at improving healthcare outcomes. Its dedicated research teams leverage cutting-edge methodologies and a diverse range of expertise to address critical health challenges. As a clinical trial sponsor, the university prioritizes ethical standards and the welfare of participants, contributing significantly to the global body of medical knowledge and the development of new therapeutic interventions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Athens, , Greece
Patients applied
Trial Officials
Asimina Mitrakou, Associate Prof.
Study Director
Department of Diabetes and Metabolism Unit of the Department of Clinical Therapeutics, National and Kapodistrian University of Athens
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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