Prucalopride in Postoperative Ileus

Launched by UNIVERSITY OF AUCKLAND, NEW ZEALAND · Oct 25, 2016

Keywords

ClinConnect Summary

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Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients from Auckland District Health Board catchment
• • Age 18 or older
• • Elective and subacute surgery
• • Right hemicolectomy, left hemicolectomy, sigmoid colectomy, anterior resection, Hartmann's procedure, subtotal colectomy
• • Operation with or without the formation of a colostomy
• • Indication for operation: colon cancer, diverticular disease, gynaecological
• • Able to understand risks and benefits of the study
• • Able to give informed consent
• Exclusion Criteria:
• • ASA 4 or greater
• • Allergy to any serotonin medication
• • Active inflammatory bowel disease
• • Planned formation of an ileostomy during surgery
• • Moderate to severe renal impairment (Creatinine clearance\<50mL/min/1.73m2)
• • Severe hepatic impairment (Child-Pugh C)
• • Pregnancy
• • Pre-existing gut dysmotility disorder including endocrine, metabolic or neurological cause
• • Pre-operative malnutrition requiring parenteral nutrition
• • Inability to give consent or participate in post-operative assessments due to dementia, cognitive impairment, language difficulties, delirium