Shandong Cancer Hospital Affiliated to Shandong University

Launched by SHANDONG CANCER HOSPITAL AND INSTITUTE · Nov 4, 2016

Keywords

ClinConnect Summary

This clinical trial is studying two different types of radiation therapy for women with early-stage breast cancer who have had breast-conserving surgery. The goal is to compare an accelerated treatment, which delivers higher doses of radiation over a shorter period, to a more traditional approach that spreads the treatment out over a longer time. Researchers want to find out if the faster method is just as safe and effective as the standard treatment in terms of side effects, how well it controls cancer, and overall survival.

To participate in this study, women must be between 18 and 65 years old, have been diagnosed with invasive breast cancer, and have undergone breast-conserving surgery. They cannot have had a mastectomy or certain other treatments that could affect their eligibility. Those who join will receive radiation therapy and will be monitored for side effects and outcomes. The trial is currently recruiting participants, so if you meet the criteria and are interested, you could be part of an important effort to improve treatment for breast cancer.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Female patients has had breast conserving surgery
• • 2. age ≥ 18 and ≤ 65 years
• • 3. with a histological diagnosis of invasive carcinoma of the breast
• • 4. with pathological stage of T1-2N0-1M0
• • 5. multidisciplinary decision of adjuvant WBI with a boost to the tumor bed
• • 6. informed consent obtained, signed and dated before specific protocol procedures
• Exclusion Criteria:
• • 1. patients treated with Mastectomy
• • 2. Need for lymph node irradiation
• • 3. positive or close(≤ 1 mm) surgical margin
• • 4. treated with neoadjuvant chemotherapy before surgery
• • 5. Bilateral malignancy of the breast (synchronous or metachronous)
• • 6. Pregnant or breastfeeding
• • 7. Mental condition rendering the patient unable to understand the nature, scope and possible consequences of the study
• • 8. Patient unlikely to comply with the protocol; i.e. uncooperative attitude, inability to return for follow-up visits, and unlikely to complete the study