Remote Ischemic Preconditioning on Pulmonary Injury in Cardic Surgery

Launched by XUZHOU MEDICAL UNIVERSITY · Jan 7, 2017

Keywords

ClinConnect Summary

Remote ischemic preconditioning (RIPC) protocol will be induced during anesthesia by 3 cycles of 5-min upper limb ischemia and 5-min reperfusion using a blood pressure cuff inflated to a pressure 200mmHg

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients undergoing heart surgery on cardiopulmonary bypass
• • 2. Patients aged 18 years to 80 years
• Exclusion Criteria:
• • 1. Inability to give informed consent
• • 2. Preoperative severe impairment of respiratory function (arterial oxygen tension (PaO2) \<60 mmHg or FEV1\<50% predicted)
• • 3. Prior receipt of chemotherapy or radiation therapy or immunotherapy
• • 4. left ventricular ejection fraction less than 30%
• • 5. preoperative use of inotropics or mechanical assist device
• • 6. Patients with significant hepatic dysfunction (Prothrombin\>2.0 ratio)
• • 7. Patients with known renal failure with a GFR\<30 mL/min/1.73 m2
• • 8. recent myocardial infarction (within 7 days)
• • 9. Systemic or local active infections (either clinically defined or suggested by evidence such as elevated C-reactive protein levels, leukocytosis, or a body temperature\>38℃)
• • 10. Significant peripheral arterial disease affecting the upper limbs
• • 11. surgeries: cardiac transplantation, concomitant carotid endarterectomy , previous heart surgery,, off-pump surgery, emergency surgery