Breathing-Induced Myocardial Oxygenation Reserve

Launched by MCGILL UNIVERSITY HEALTH CENTRE/RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE · Feb 8, 2017

Keywords

ClinConnect Summary

This is a clinical trial to test the clinical feasibility and safety of a novel CMR protocol. It aims to investigate a new Cardiovascular Magnetic Resonance (CMR) technique, called oxygenation-sensitive CMR (OS-CMR).

OS-CMR is a T2\*-sensitive CMR sequence based on the so-called blood-oxygen-level-dependent (BOLD) effect. Because de-oxygenated hemoglobin acts as an endogenous paramagnetic contrast agent, the signal intensity (SI) in OS-CMR images is linearly correlated with hemoglobin oxygenation in the tissue. An increase in deoxyhemoglobin results in an drop in SI in OS-CMR images, while...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age \> 18 y
• • Informed consent as documented by signature (Appendix Informed Consent Form)
• • Indication for invasive coronary angiography based on symptoms and a test positive for inducible coronary ischemia
• • One-vessel or two-vessel CAD at coronary angiography (For healthy volunteers: absence of current or pre-existing cardiovascular and lung disease and absence of medication with cardiovascular effects)
• Exclusion Criteria:
• • General MRI contraindications (i.e pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, knowledge or suspicion of pregnancy)
• • Acute Coronary Syndrome (ACS) or other acute cardiac injury within 4 weeks
• • Previous myocardial infarction, percutaneous coronary intervention or coronary artery bypass surgery
• • Hemodynamically unstable conditions
• • Significant or uncontrolled arrhythmias
• • Lack of ability to follow commands
• • Vasoactive medication (e.g. nitro or ß blockers) or nutrition with caffeine (coffee, tea, cocoa, chocolate, "energy drink") during the 12 h before the exam
• • Non-ischemic cardiomyopathy
• • Severe Pulmonary Disease