A Study Of Lorlatinib Versus Crizotinib In First Line Treatment Of Patients With ALK-Positive NSCLC

Launched by PFIZER · Feb 9, 2017

Keywords

ClinConnect Summary

This clinical trial is studying two medications, lorlatinib and crizotinib, to see which one works better for patients with a specific type of lung cancer called ALK-positive non-small cell lung cancer (NSCLC) who have not received treatment before. The main goal is to find out if lorlatinib can help patients live longer without their cancer getting worse compared to crizotinib. The trial is currently active but not recruiting new participants.

To be eligible for this study, participants need to be at least 18 years old and have a confirmed diagnosis of advanced ALK-positive NSCLC. They should have at least one measurable tumor that has not been treated with radiation before and must not have received any previous systemic (whole-body) treatment for NSCLC. Eligible participants will also need to meet certain health criteria, including good functioning of their organs and no significant heart problems. If you or a loved one is considering participating, it’s important to discuss this with a healthcare provider to understand if this trial is a good option. Participants can expect to be monitored closely throughout the study to evaluate the effectiveness and safety of the treatments.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Histologically or cytologically confirmed diagnosis of locally advanced or metastatic ALK-positive NSCLC; at least 1 extracranial measurable target lesion not previously irradiated. CNS metastases allowed if asymptomatic and not currently requiring corticosteroid treatment.
• • Availability of an archival FFPE tissue specimen.
• • No prior systemic NSCLC treatment.
• • ECOG PS 0, 1, or 2.
• • Age ≥18 years .
• • Adequate Bone Marrow, Liver, Renal, Pancreatic Function
• • Negative pregnancy test for females of childbearing potential
• Exclusion Criteria:
• • Spinal cord compression unless good pain control attained
• • Major surgery within 4 weeks prior to randomization.
• • Radiation therapy within 2 weeks prior to randomization, including stereotactic or partial brain irradiation. Whole brain irradiation within 4 weeks prior to randomization
• • Active bacterial, fungal, or viral infection
• • Clinically significant cardiovascular disease, active or within 3 months prior to enrollment. Ongoing cardiac dysrhythmias, uncontrolled atrial fibrillation, bradycardia or congenital long QT syndrome
• • Predisposing characteristics for acute pancreatitis in the last month prior to randomization.
• • History of extensive, disseminated, bilateral or presence of Grade 3 or 4 interstitial fibrosis or interstitial lung disease
• • Active malignancy (other than NSCLC, non melanoma skin cancer, in situ cervical cancer, papillary thyroid cancer, LCIS/DCIS of the breast, or localized prostate cancer) within the last 3 years prior to randomization.
• • Concurrent use of any of the following food or drugs within 12 days prior to the first dose of lorlatinib or crizotinib.
• • 1. known strong CYP3A inhibitors .
• • 2. known strong CYP3A inducers
• • 3. known P gp substrates with a narrow therapeutic index
• • Concurrent use of CYP3A substrates with narrow therapeutic indices within 12 days prior to the first dose of lorlatinib or crizotinib.
• • Other severe acute or chronic medical or psychiatric condition, including recent or active suicidal ideation or behavior, or laboratory abnormality that may increase the risk associated with study participation or interfere with the interpretation of study results
• • Investigational site staff members directly involved in the conduct of the study and their family members, or Pfizer employees, including their family members, directly involved in the conduct of the study.
• • Participation in other studies involving investigational drug(s) within 2 weeks prior to study entry and/or during study participation.