Vitamin D Repletion and Maintenance in IBD: How Much and How Often

Launched by CEDARS-SINAI MEDICAL CENTER · Feb 10, 2017

Keywords

ClinConnect Summary

Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn's disease (CD), are chronic relapsing inflammatory conditions of the gastrointestinal tract. IBD is thought to result from a complex interaction between genetic, immune, microbial and environmental factors. The role of vitamin D in bone health and calcium homeostasis is well documented. However, emerging data suggests that vitamin D may also regulate immune responses, which may play a role in the pathogenesis and disease activity of IBD.

The investigators seek to identify CD or UC patients with mild disease ...

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Eligibility criteria

• Inclusion Criteria:
• • 1. Diagnosis of Crohn's disease or Ulcerative colitis
• • 2. In clinical remission or with mild disease activity as determined by the Harvey Bradshaw Index (CD) ≤7 or Ulcerative Colitis disease activity index ≤6.
• • 3. 25(OH)D level \<30 ng/ml within three months of study enrollment
• • 4. Provided verbal consent
• • 5. 18 years of age or older
• Exclusion Criteria:
• • 1. Unwilling to provide consent or lack capacity
• • 2. Moderate to severe disease activity (Harvey Bradshaw index \>7 or UCDAI \>6)
• • 3. Current pregnancy or attempting to conceive
• • 4. Known coexisting hyperparathyroidism
• • 5. Already on vitamin D supplementation, calcium supplementation or a multivitamin
• • 6. BMI \>30 kg/m²
• • 7. History of kidney stones
• • 8. Subjects \<18 years of age - pediatric population with different recommended dosing than adults (10).
• • 9. Non-english speakers