Effect of Paracetamol on Renal Function in Plasmodium Knowlesi Malaria

Launched by MENZIES SCHOOL OF HEALTH RESEARCH · Feb 14, 2017

Keywords

ClinConnect Summary

Plasmodium knowlesi is the most common cause of malaria, and malaria deaths, in Sabah, Malaysia. Acute kidney injury (AKI) is a common feature of severe knowlesi malaria; however the mechanisms of AKI in knowlesi malaria are unknown. In falciparum malaria, recent evidence suggests that oxidative stress from haemolysis-related cell-free haemoglobin (CFHb) may contribute to pathogenesis of AKI.

Cell-free haemoglobin and oxidative stress: CFHb is released during intravascular haemolysis, and when exceeding the binding capacity of plasma haptoglobin, is filtered by the glomeruli and enters the...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patient age ≥ 5 years
• • 2. Presence of P. knowlesi malaria, confirmed by positive blood smear with asexual forms of P. knowlesi.
• • 3. Temperature \>38C on admission or fever during the preceding 48 hours
• • 4. Enrolled within 18 hours of commencing antimalarial treatment
• • 5. Written informed consent from patient or attending relative able to and willing to give informed consent. Consent form and information sheets will be translated into Malay and copies provided to the patient.
• Exclusion Criteria:
• • 1. Patient or relatives unable or unwilling to give informed consent
• • 2. Contraindication or allergy to paracetamol or artesunate therapy
• • 3. Known cirrhosis, or \>6 standard alcoholic drinks/day
• • 4. Pregnancy