Vitamin C in Cardiac Surgery Patients
Launched by GEISINGER CLINIC · Apr 19, 2017
Trial Information
Current as of April 25, 2025
Completed
Keywords
ClinConnect Summary
The pathophysiology of post-operative atrial fibrillation (POAF) in cardiac surgery patients has not been fully elucidated, but inflammation and oxidative stress are associated with its occurrence. Increased activity of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and production of glutathione and nitrotyrosine have been found to occur in animal models of atrial fibrillation and patients who develop POAF. Similarly, malondialdehyde (MDA), a biomarker of lipid peroxidation, has also been shown to increase during cardiac surgery, and be significantly more elevated in patients w...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Patients 21 to 79 years of age admitted to Geisinger Wyoming Valley (GWV) and scheduled to undergo urgent CABG
- • Planned utilization of cardiopulmonary bypass during the surgical procedure
- Exclusion Criteria:
- • Body mass index greater than 30 kg/m2
- • Estimated creatinine clearance less than 30 ml/min
- • History of persistent or permanent atrial fibrillation
- • Condition associated with oxidative stress or inflammation (e.g. chronic rheumatic, inflammatory or neoplastic disease, recent infection, etc.)
- • Currently taking corticosteroids, non-steroidal anti-inflammatory drugs or deferoxamine
- • History of oxalate kidney stones
- • Currently pregnant
- • History of allergic reaction to ascorbic acid products
- • Currently taking any herbals or supplements (not including a multivitamin or calcium)
- • Enrolled in another research study
About Geisinger Clinic
Geisinger Clinic is a leading healthcare organization based in Pennsylvania, recognized for its commitment to innovative patient care and research. As a clinical trial sponsor, Geisinger Clinic integrates cutting-edge medical research with a focus on improving health outcomes through evidence-based practices. The organization leverages its extensive electronic health record system and diverse patient population to facilitate comprehensive clinical studies that advance medical knowledge and enhance therapeutic options. With a strong emphasis on collaboration and community engagement, Geisinger Clinic aims to translate research findings into practical solutions that benefit patients and the healthcare system as a whole.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Wilkes Barre, Pennsylvania, United States
Patients applied
Trial Officials
Deepak Singh, MD
Principal Investigator
Geisinger Clinic
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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