Periodontal Debridement Associated With Systemic Antibiotics and Single/Repeated PDT to Treat Aggressive Periodontitis

Launched by UNIVERSIDADE ESTADUAL PAULISTA JÚLIO DE MESQUITA FILHO · Apr 26, 2017

Keywords

ClinConnect Summary

The study methodology is according to CONSORT-STATEMENT 2010 and SPIRIT 2013 for randomized controlled clinical trials.

Study Design

The study is designed as a prospective, interventional, parallel, blinded, randomized, controlled clinical trial aimed to compare the efficacy and the local effect of the association of single or repeated application of photodynamic therapy (PDT) with antibiotic agents using Amoxicillin + Metronidazole or Clarithromycin in the treatment of patients with Generalized Aggressive Periodontitis (GAgP).

Source of data

The population of this study will be recruit...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • diagnosis of GAgP (Armitage, 1999; American Academy of Periodontology, 2015);
• • presence of ≥20 teeth, excluding third molars and teeth indicated for extraction;
• • presence of ≥6 sites presenting PD ≥5 mm with bleeding on probing and ≥2 sites with PD ≥7 mm (including incisors and first molars, in addition to two other non-contiguous teeth between them);
• • presence of three non-adjacent periodontal pockets with probing depth ≥5 mm and bleeding on probing not located in furcation area;
• • good general health (ASA I/II);
• • 18-35 years old;
• • agree to participate in the study and sign a written consent (Resolution # 196 of October 1996 and the Brazilian Professional Code of Dental Ethics - 179/93).
• Exclusion Criteria:
• • pregnant or nursing;
• • suffer from any systemic disease (e.g. cardiovascular, diabetes, blood dyscrasias, immunodeficiency, etc - ASA III/IV/V);
• • antimicrobials or anti-inflammatory drugs in the previous 6 months;
• • periodontal treatment within the last 12 months;
• • smoke ≥10 cigarettes/day;
• • reported allergy to amoxicillin, metronidazole or clarithromycin;
• • required antibiotic prophylaxis;
• • current use of any medication that could interfere with periodontal response were excluded from the study.