Efficacy and Safety of Terlipressin With Albumin Versus Midodrine With Albumin Versus Albumin Alone in Prevention of Paracentesis Induced Circulatory Dysfunction in Cirrhosis

Launched by INSTITUTE OF LIVER AND BILIARY SCIENCES, INDIA · May 8, 2017

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Eligibility criteria

• Inclusion Criteria:
• • 1. Patients with cirrhosis who undergo Large volume paracentesis (\> 5L)
• • 2. Patients with age from 18-75 years
• Exclusion Criteria:
• • 1. Renal failure ( Creatinine\>1.5mg/dl)
• • 2. Recent Gastrointestinal bleeding within 7 days
• • 3. Spontaneous bacterial Peritonitis
• • 4. Patients with Cardiovascular disease (Electrocardiogram, 2D Echo)
• • 5. Systemic arterial hypertension ( \>160/90mmhg) Presence of hepatocellular carcinoma or portal vein thrombosis, Budd chiari syndrome
• • 6. Patients with active untreated sepsis
• • 7. Pregnancy
• • 8. Patients with hepatic encephalopathy
• • 9. No use of drugs affecting systemic hemodynamic 3 days prior to enrollment
• • 10. Refusal to participate