Comparison of Oral Paracetamol and Zolmitriptan Efficacy in the Treatment of Acute Migraine in Emergency Department

Launched by PAMUKKALE UNIVERSITY · May 8, 2017

Keywords

ClinConnect Summary

* This is prospective, randomized, controlled research to compare the efficacy of these two drugs in emergancy department.
* The clinical trial was conducted in the ED of Pamukkale University Medical Faculty Hospital.
* Study personnel (emergency physicians and nurses) were trained before the study.
* When oral drugs (paracetamol, zolmitriptan was being recommended, an eligibility checklist was completed by the attending physician.
* If there were no exclusion criteria, written informed consent was obtained and baseline information, including initial headache pain score ratings with VAS and...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients were eligible for inclusion if they were aged 18 years or older, 65 years or younger
• • Had acute migraine attack without aura
• • VAS (visual analog scale) score \>50 mm , NRS (Numeric Rating Scale) score \>5
• • Patients whose written consent is obtained by agreeing to participate in the study
• Exclusion Criteria:
• • Those who refuse to participate in the work
• • Patients younger than 18 years or older than 65 years
• • Those who use ergotamine derivative drugs in the last 24 hours
• • Have received analgesics in the last 6 hours
• • Patients with severe liver, kidney, lung and heart failure
• • To have active peptic ulcer bleeding or perforation
• • Have a history of upper gastrointestinal disease
• • To be Pregnancy and breast-feeding
• • Patients of childbearing age who are not using a birth control method.
• • Allergy to medicines used in work
• • Hemodynamically unstable patients
• • Patients with renal transplantation
• • Blood pressure uncontrolled hypertension patients
• • Patients with cerebrovascular disease history
• • Patients with ischemic heart disease or coronary spasm / printzmetal angina
• • Patients with arrhythmia accompanying Wolff-Parkinson-White syndrome or accessory conduits in the heart
• • Patients with Glucose 6 Phosphate Dehydrogenase (G6PD) deficiency
• • Those with other systemic diseases,
• • Patients with a Visual Analogue Scale (VAS) pain score less than 50 mm
• • Illiterates and patients with vision problems