Effect Of Curcuma Xanthorrhiza and Vitamin D3 Supplementation in SLE Patients With Hypovitamin D

Launched by SAIFUL ANWAR HOSPITAL · May 13, 2017

Keywords

ClinConnect Summary

Cholecalciferol 1200 IU supplementation for 3 months in hypovitamin D SLE patients, decrease SLEDAI, however, it has not reached the mild activity and remission yet. Curcumin contained in Curcuma Xanthorrhiza; is an immunomodulator that has similar biological effect with vitamin D. Combination of curcumin and vitamin D are expected to work synergistically.

The subjects who fulfilled inclusion criteria, willing to participate in the research and signed the informed consent were 40 patients. Research subjects were randomized using simple randomization. The subjects were divided into 2 groups...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • SLE based on the criteria of American Collage of Rheumatology (ACR) 1997
• • Active SLE (SLEDAI\> 3)
• • 25(OH)D level \<30 ng/ml.
• Exclusion Criteria:
• • Pregnant
• • Taking supplements containing vitamin D and cur cumin
• • Had liver function disorders (SGOT/SGPT levels\> 2.5 times the upper normal limit)
• • Had impaired renal function (GFR \<25 ml/min)
• • Severe infections such as tuberculosis, pneumonia or HIV