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Search / Trial NCT03169946

Chlorhexidine-Metronidazole Combination as an Intracanal Medicament on Periodontal Healing

Launched by POSTGRADUATE INSTITUTE OF DENTAL SCIENCES ROHTAK · May 25, 2017

Trial Information

Current as of May 15, 2025

Unknown status

Keywords

ClinConnect Summary

INTRODUCTION

The pulp tissue within the tooth and surrounding periodontium are interrelated to each other due to structural, functional and microbiological similarities. Cross infection of bacterial colonies take place in between these sites through dentinal tubules, apical foramen, lateral and accessory canals.Concurrent endodontic- periodontic lesions are those lesions where both endodontic and periodontal diseases occurring at same time in relation to single tooth.

Endodontic infection present in tooth is responsible for more bone loss, attachment loss and results in impaired healing o...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • * Patients of age between 18-55 years with generalized chronic periodontitis will be enrolled, having at least one tooth with concurrent endodontic periodontal lesion with communication including following features:
  • a clinical and radiographic diagnosis of concurrent endodontic periodontal lesion
  • Wide base pocket, deep probing pocket depth
  • Non vital tooth on the basis of pulp sensibility tests along with periapical radiolucency
  • Radiographic alveolar bone (marginal bone) destruction with apical communication
  • Patients of generalized chronic periodontitis will be selected on the basis of Armitage classification of periodontal diseases and conditions \[≥30% sites involved with clinical attachment level (CAL) 1-2mm (mild) or 3-4mm (moderate) or ≥5mm (severe)\]
  • Patients should have more than 20 teeth in their oral cavity excluding third molars.
  • Exclusion Criteria:
  • Systemic illness known to affect the periodontium or outcome of periodontal therapy.
  • Patient taking medications such as corticosteroids, calcium channel blockers and anticoagulant therapy, which are known to interfere periodontal wound healing or patient on long term NSAID therapy or bisphosphonates.
  • Patients allergic to medication (chlorhexidine, local anaesthetic, antibiotics, NSAID).
  • Patients with acute symptoms.
  • Pregnant or lactating females.
  • Smokers (current and past) and tobacco chewers.
  • Grade 3 mobile teeth.
  • Unrestorable tooth.
  • Root resorption.
  • Fractured/perforated roots.
  • Developing permanent tooth.
  • Abutments.
  • Previously root canal filled tooth.
  • Patients with aggressive periodontitis
  • History of periodontal treatment within 6 months prior to study.

About Postgraduate Institute Of Dental Sciences Rohtak

The Postgraduate Institute of Dental Sciences, Rohtak, is a premier academic institution dedicated to advancing dental education, research, and clinical practice. With a commitment to fostering innovation in oral health, the institute is actively engaged in conducting clinical trials that aim to enhance treatment methodologies and improve patient outcomes. By integrating cutting-edge research with comprehensive training, the institute plays a pivotal role in shaping the future of dental sciences, while adhering to the highest ethical standards and regulatory guidelines in clinical research.

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Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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