A New Application of Amiloride in the Treatment of Patient With Chronic Kidney Disease In Reducing Urinary PROtein

Launched by GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL · May 26, 2017

Keywords

ClinConnect Summary

Amiloride is a Na+ channel blocker and has been used as a diuretic. It mainly inhibits the exchange of Na+-K+ and Na+-H+ in the distal tubule and collecting duct of the kidney, thus increasing the excretion of Na+ and water, reducing the excretion of K+ and H+. Recent studies have found a significant increase in urine uPA in patients with massive proteinuria.Urine uPA concentration were positively correlated with urinary protein and decreased with remission of proteinuria. In children and adults with nephrotic syndrome,as well as rat with proteinuria induced by puromycin amino-nucleoside, a...

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Eligibility criteria

• Inclusion Criteria:
• • Patients at the age of more than 14 years old with chronic kidney disease
• • Good compliance of treatment
• • PCR≥500mg/g.cr ，more than double confirmed
• • Patients who written informed consent
• Exclusion Criteria:
• • less than 14 years of age
• • eGFR≤30ml/min.1.73m2；
• • poor compliance of treatment
• • Previously intolerant or allergic to hydrochlorothiazide
• • Patients with history of gout within six months
• • Patients with active infection
• • Patients with severe cardiopulmonary disease and dysfunction of central nervous system
• • history of malignancy
• • life expectancy is less than 1 years
• • women who are pregnant,lactating and lack of contraception.
• • enrolled in other clinical trials within 3 months
• • patients who have used immunosuppressive agents or corticosteroids recently or in the past 12 weeks.
• • patients without informed consent written or who enable or unwilling to comply with protocol approved by researchers.