Serum IL-21 Levels in Patients With Pemphigus Vulgaris

Launched by ASSIUT UNIVERSITY · Jun 4, 2017

Keywords

ClinConnect Summary

Clinically, there are localized or generalized flaccid bullae that quickly transform into post-bullous erosions and crusts , PV patients characteristically develop oral lesions with buccal and/or gingival persisting erosions (mucosal dominant PV) which several weeks or months later may also spread to the epidermis (mucocutaneous PV). PF is characterized by widespread cutaneous fragile bullae which rapidly rupture, resulting in erosions, crusting, and scaling. In contrast to PV, the mucosa is usually not involved in PV. (Zenzo .et al .,2015).

Pathophysiologically, the underlying intraepithe...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 20 pemphigus vulgaris patients
• • healthy age and sex matched
• Exclusion Criteria:
• • - Patients with a history of topical or systemic treatment (corticosteroids, intralesional steroid injection, immunosuppressive therapy, anticonvulsants and anticancer medications, within 4 weeks of the study.
• • Patients receiving phototherapy within 6 months of the study .
• • Patients with a history of diabetes mellitus, anemia, thyroid or parathyroid disorders, chronic liver or renal diseases, or atopy .
• • Patients with known autoimmune diseases or cancer.
• • Pregnant or lactating women were also excluded from the study.