Does Automated Closed-Loop Ventilation Reduce the DRiving Pressure Levels in Patients With ARDS
Launched by ACADEMISCH MEDISCH CENTRUM - UNIVERSITEIT VAN AMSTERDAM (AMC-UVA) · Jul 6, 2017
Trial Information
Current as of May 20, 2025
Terminated
Keywords
ClinConnect Summary
- Objective:
The objective of this crossover study and randomized controlled trial (RCT) is to compare ΔP levels during INTELLiVENT®- adaptive support ventilation (ASV) with conventional lung protective ventilation in the acute and sub-acute phase of moderate or severe ARDS.
- Study design:
Single center crossover study (in the acute phase) and RCT (in the sub-acute phase).
- Study population:
The study population consists of 48 consecutive intubated and ventilation patients with moderate or severe ARDS according to the Berlin definition with an anticipated duration of mechanical venti...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Admission to the ICU of the AMC
- • Intubated and mechanically ventilated
- • Within 24 hours of initial diagnosis of ARDS
- • Moderate or severe ARDS (according to the Berlin definition for ARDS)
- Exclusion Criteria:
- • Age \< 18 years
- • Patients previously included in this study
- • Patients participating in other interventional trials that could influence ventilator settings and ventilation parameters
- • Patients with suspected or confirmed pregnancy
- • Patients with increased (of \> 15 mmHg) or uncontrollable intracranial pressure
- • Patients in whom esophageal pressure measurement is contra-indicated (severe bleeding diathesis, suspicion of or known pharyngeal or esophageal obstruction, esophageal ulcers, varices or strictures)
- • Moribund patients
About Academisch Medisch Centrum Universiteit Van Amsterdam (Amc Uva)
The Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) is a leading academic medical center in the Netherlands, dedicated to advancing healthcare through innovative research, education, and patient care. Affiliated with the University of Amsterdam, AMC-UvA integrates clinical practice with cutting-edge biomedical research, fostering a multidisciplinary approach to medical challenges. The institution actively engages in clinical trials to enhance treatment options and improve patient outcomes, while promoting collaboration among healthcare professionals, researchers, and academic institutions globally. With a commitment to excellence and a focus on translational medicine, AMC-UvA plays a pivotal role in shaping the future of healthcare.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Amsterdam, , Netherlands
Patients applied
Trial Officials
David MP van Meenen, MD, MSc
Study Director
Department of Intensive Care, Academic Medical Center, University of Amsterdam
Marcus J Schultz, MD, PhD
Principal Investigator
Department of Intensive Care, Academic Medical Center, University of Amsterdam
Marcello Gama de Abreu, MD, PhD
Study Chair
Department of Anesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Technical University Dresden, Germany
Ary Serpa Neto, MD, MSc
Study Chair
Department of Intensive Care, Academic Medical Center, University of Amsterdam, The Netherlands
Paolo Pelosi, MD, PhD
Principal Investigator
Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Italy
Jitske R Rogmans
Principal Investigator
Department of Intensive Care, Academic Medical Center, University of Amsterdam
Lennard HL Pennekamp
Principal Investigator
Department of Intensive Care, Academic Medical Center, University of Amsterdam
Frank C Dullemeijer
Principal Investigator
Department of Intensive Care, Academic Medical Center, University of Amsterdam
Marco Maggiorini, MD, PhD
Principal Investigator
Department of Intensive Care, Universitatsspital, Zurich
Dominik Novotni, MD, PhD
Study Chair
Hamilton Medical AG
Alexandra Gerlach
Principal Investigator
Hamilton Medical AG
Job BM van Woensel, MD, PhD
Study Chair
Department of Intensive Care, Academic Medical Center, University of Amsterdam
Jean-Michel Arnal, MD, PhD
Study Chair
Department of Intensive Care, Intercommunal hospital, Toulon
Patricia Rocco, MD, PhD
Principal Investigator
Laboratory of pulmonary investigation, Federal University, Rio de Janeiro
Dave A Dongelmans, MD, PhD
Principal Investigator
Department of Intensive Care, Academic Medical Center, University of Amsterdam
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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