The Effect of Probiotics on Chronic Kidney Disease

Launched by CHINA MEDICAL UNIVERSITY HOSPITAL · Jul 21, 2017

Keywords

ClinConnect Summary

Chronic kidney disease (CKD) is a global health issue that has a substantial impact on affected individuals. Chronic inflammation, which is widely seen in CKD including long-term dialysis patients, is associated with malnutrition, atherosclerosis and an increased mortality risk. Inflammatory markers such as C-reactive protein, IL-6, IL-18, and TNF-α, are elevated in dialysis patients and can predict cardiovascular event and all-cause mortality. Endotoxin is bacterial lipopolysaccharide, and makes up the outer membrane of Gram-negative bacteria. Endotoxin is also an important source and also...

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Eligibility criteria

• Healthy volunteers:
• • The criteria for healthy volunteers were: no hypertension (Blood pressure\<140/90mmHg), no diabetes (Glucose AC 70\~100mg/dl), no hyperlipidemia (Cholesterol Total 130\~200mg/dL、Triglyceride\<150mg/dL), no urinary protein (-) and normal renal function (eGFR\>90), after signing the consent form, the stool samples will be collected.
• CKD patients:
• Inclusion Criteria:
• • ‧Stage 3-5 CKD patients, at least 20 years of age and regular follow-up for at least 6 months prior to enrollment.
• Exclusion Criteria:
• • Pregnancy.
• • On immunosuppressive therapy.
• • Active infectious condition.
• • Acute kidney injury.
• • Consuming other forms of probiotics.
• • Taking antibiotics within 30 days prior to enrollment.