Predicting Pathological Complete Response of Rectal Cancer With Magnetic Resonance(MR) Radiomics

Launched by SUN YING-SHI · Aug 1, 2017

Keywords

ClinConnect Summary

We propose to develop and validate a radiomics model for individualized pCR evaluation after CRT in patients with LARC. We plan to use both pre- and post-CRT MRI data to construct the predictive radiomics model for evaluating if LARC patients achieve pCR after CRT. The ultimate aim is to select appropriate LARC patients for omission of surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • pathologically proved rectal cancer
• • locally advanced rectal cancer (≥T3 or N+)
• • a distance less than 12cm between the lower edge of tumor and the anal margin
• • no evidence of distant metastases
• • no prior anti-cancer therapy before treatment
• • scheduled to receive preoperative CRT
• Exclusion Criteria:
• • history or concurrent of other malignancy
• • incomplete preoperative CRT
• • failed to receive surgery or unavailable pCR assessment
• • poor quality of MR images for measurement
• • patient quit