Mediterranean Diet and the Gut Microbiome

Launched by WAKE FOREST UNIVERSITY HEALTH SCIENCES · Aug 30, 2017

Keywords

ClinConnect Summary

Irritable bowel syndrome (IBS) is the most prevalent and well-studied functional gastrointestinal disorder. While IBS has no direct mortality, it does compromise quality of life, incurs morbidity, and has a substantial economic impact on society. The gut microbiome may play a significant role in the pathogenesis of IBS. Even though the exact mechanisms underlying this relationship have not been presented, it is suggested that certain microorganisms may increase gut permeability, activate the mucosal immune response, increase visceral sensitivity and alter intestinal motility via a bidirecti...

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Eligibility criteria

• Inclusion Criteria:
• • must be willing to eat pre-prepared foods for 4 weeks
• • subjects must have no medical, religious, or cultural dietary restrictions that would preclude their eating a Mediterranean diet.
• • Phase 2 subjects- must have diagnosis of IBS based on Rome III criteria and have diarrhea-predominant disease, defined as \>50% of bowel movements characterized as diarrhea
• Exclusion Criteria:
• • history of gastrointestinal disease, including celiac disease, inflammatory bowel disease, or lactose intolerance
• • diabetes mellitus
• • congestive heart failure
• • coronary artery disease
• • chronic liver disease or end stage renal disease
• • pregnancy or breastfeeding
• • trainees under the direct supervision of the PI and patients receiving direct ongoing medical care from the PI or Co-I will not be enrolled as subjects in this study