Genetic Variants and Oxidative Stress as Links Between Periodontitis and Metabolic Syndrome
Launched by UNIVERSITY COLLEGE, LONDON · Sep 26, 2017
Trial Information
Current as of June 05, 2025
Unknown status
Keywords
ClinConnect Summary
This is a cross-sectional study. 102 patients with metabolic syndrome will be recruited and will have periodontal and dental examination for diagnosis of caries and periodontal diseases. They will undergo blood, saliva, GCF and subgingival plaque sampling and a series of tests on cardiovascular disease, including measures of pulse-wave velocity,carotid intima-media thickness and echocardiography assessment. Statistical analysis will assess associations between dental diagnoses and metabolic, cardiovascular, inflammatory, genetic, microbial and cardiovascular risk outcomes.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Caucasian ethnicity
- • Age 18- 75
- • Diagnosis of metabolic syndrome
- • Presence of at least 12 teeth
- Exclusion Criteria:
- • Pregnancy
- • Presence of infectious diseases such as hepatitis and HIV
- • Use of non-steroidal anti-inflammatory drugs (excluding low-dose aspirin) within one month prior to the baseline visit
- • Use of systemic antibiotics within three months prior to the baseline visit
- • Antibiotic pre-medication required for the performance of periodontal examination
About University College, London
University College London (UCL) is a leading global research institution renowned for its commitment to advancing healthcare through innovative clinical trials. As a prominent sponsor of clinical research, UCL leverages its multidisciplinary expertise and state-of-the-art facilities to conduct rigorous investigations aimed at improving patient outcomes and addressing pressing medical challenges. The institution fosters collaboration among researchers, healthcare professionals, and industry partners, ensuring that its trials adhere to the highest ethical standards and regulatory guidelines. UCL's dedication to translating scientific discoveries into practical applications underscores its role as a vital contributor to the advancement of medical science and public health.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Catania, , Italy
London, , United Kingdom
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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