The Impact of a Nutritional Supplement (Impryl®) on Male Fertility
Launched by RADBOUD UNIVERSITY MEDICAL CENTER · Nov 6, 2017
Trial Information
Current as of May 02, 2025
Active, not recruiting
Keywords
ClinConnect Summary
This clinical trial is investigating the effects of a nutritional supplement called Impryl® on male fertility, specifically for men who are part of couples struggling to conceive. Infertility affects many couples, and in about half of these cases, a male factor plays a role. The study aims to see if taking Impryl®, which contains vitamin B and supports the body's metabolism, can help increase the chances of pregnancy for these couples, whether they are using assisted reproductive technologies like IVF or not.
To participate in this trial, men must be between the ages of 18 and 50 and be part of a couple that has been trying to conceive for at least a year, or is starting their first, second, or third cycle of treatments like Intrauterine Insemination (IUI) or IVF. It's important to note that certain medical conditions or treatments may exclude individuals from participating, such as previous surgeries related to fertility or the use of donor sperm. Participants can expect to take the supplement as directed and contribute to research that could improve fertility options for men facing similar challenges.
Gender
MALE
Eligibility criteria
- Inclusion Criteria:
- • Couples with failure to conceive for at least 12 months and starting with EM or Couples starting with 1st/ 2nd/3rd cycle of IUI (with/without ovarian stimulation) or Couples starting with 1st/ 2nd/3rd cycle of IVF/ICSI
- Furthermore:
- • Male with age 18-50 years
- • Female partner with age 18-43 years
- • Willing and able to give informed consent
- Exclusion Criteria:
- • Planned or performed diagnostic testicular biopsy (TESE) or percutaneous epididymal sperm aspiration (PESA)
- • Use of donor-, cryopreserved- or electro-ejaculated semen
- • Ovulation induction (OI) without IUI
- • IVF for an absolute tubal factor
- • Embryo-transfers after cryopreservation
- • Embryo-transfer after pre-implantation genetic diagnosis
- • Known genetic abnormalities related to infertility
- • Known urological abnormality such as a varicocele or bilateral cryptorchism
- • Use of other vitamin supplements
About Radboud University Medical Center
Radboud University Medical Center is a leading academic medical institution located in Nijmegen, the Netherlands, dedicated to advancing healthcare through innovative research and education. As a prominent sponsor of clinical trials, Radboud UMC leverages its multidisciplinary expertise to conduct high-quality research that aims to improve patient outcomes and enhance medical knowledge. The center is committed to ethical standards and regulatory compliance, fostering collaboration among researchers, healthcare professionals, and patients to translate scientific discoveries into effective clinical applications. With a focus on personalized medicine and cutting-edge technologies, Radboud University Medical Center plays a pivotal role in shaping the future of healthcare through its rigorous clinical trial initiatives.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Eindhoven, , Netherlands
Breda, , Netherlands
'S Hertogenbosch, , Netherlands
Nijmegen, , Netherlands
Rotterdam, , Netherlands
Dordrecht, , Netherlands
Nijmegen, Gelderland, Netherlands
Voorburg, Gelderland, Netherlands
Apeldoorn, , Netherlands
Arnhem, , Netherlands
Boxmeer, , Netherlands
Doetinchem, , Netherlands
Elsendorp, , Netherlands
Leiderdorp, , Netherlands
Maastricht, , Netherlands
Roosendaal, , Netherlands
Tilburg, , Netherlands
Uden, , Netherlands
Veldhoven, , Netherlands
Wolvega, , Netherlands
Emmen, , Netherlands
Gorinchem, , Netherlands
Rotterdam, , Netherlands
Patients applied
Trial Officials
Annemiek Nap, Prof.dr.
Study Director
Gynecologist, head of department of Obstetrics and Gynaecology
Annemiek Nap, Prof MD PhD
Principal Investigator
Gynecologist, head of department of Obstetrics and Gynecology
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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